Flonase Allergy Relief contains the number one prescribed allergy medicine in the US, fluticasone propionate. Once daily, Flonase–the first and only nasal spray formula indicated to offer 24-hour relief of both nasal and eye-related allergy symptoms–delivers full prescription-strength allergy treatment without a prescription. Unlike most common OTC allergy pills, Flonase helps block six allergic substances, not just one.