This mandatory safety warning indicates that a medication is formulated specifically for absorption through the rectum and must never be taken by mouth or used in any other way. Products carrying this label—such as glycerin suppositories, hemorrhoidal ointments, or medicated enemas—are designed to dissolve or be absorbed at body temperature within the rectal cavity. Swallowing these medications can lead to reduced effectiveness, choking hazards (in the case of suppositories), or severe gastrointestinal irritation. Always follow the specific insertion instructions provided by the manufacturer or your healthcare professional to ensure the medication works correctly and safely.